Ateroskleroz patofizyolojisinde Kruppel Benzeri Faktör 14’ün rolü
نویسندگان
چکیده
منابع مشابه
KLF 4 ( Kruppel - like factor 4 ( gut ) )
A full-length mouse cDNA clone encoding KLF4 was initially isolated from a NIH3T3 cDNA library by reduced stringency screening with a DNA probe containing the zinc finger region of an immediate early gene product, Zif268 or Egr1. A distinct feature of the KLF4 gene is the highly GC-rich nature of the sequence near its 5'-end. Thus, the G+C content of the 1000 nt 5'-flanking region is 67% and th...
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KLF5 is a transcription factor. Many KLF5 target genes, such as PDGFa, PPARg, NFkB, cyclinD1, KLF4, and TCR, have been identified in different cell models. KLF5 regulates cell proliferation, cell cycle, apoptosis, and differentiation. KLF5 is an important transcription factor for cardiovascular remodeling and tumor angiogenesis. KLF5 is essential for mouse embryo development. Additionally, KLF5...
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Özet Bu çalışmanın amacı yazılım mühendisliği üretkenlik ölçümleri için kullanılabilecek üretkenlik, sosyal üretkenlik ve sosyal sermaye kavramlarına dayalı (üç boyutlu) bir ölçek geliştirmektir. Bu amaç doğrultusunda yazılım geliştirme süreçlerini etkileyen etmenlerin sosyal ve teknik boyutları ve birbirleri ile olan ilişkileri hem teorik hem de pratik boyutta sorgulanmıştır. Araştırmanın teor...
متن کاملKruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes.
The mechanisms regulating activation of monocytes remain incompletely understood. Herein we provide evidence that Kruppel-like factor 2 (KLF2) inhibits proinflammatory activation of monocytes. In vitro, KLF2 expression in monocytes is reduced by cytokine activation or differentiation. Consistent with this observation, KLF2 expression in circulating monocytes is reduced in patients with chronic ...
متن کاملExpression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle re...
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ژورنال
عنوان ژورنال: Mersin Üniversitesi Sağlık Bilimleri Dergisi
سال: 2020
ISSN: 1308-0830
DOI: 10.26559/mersinsbd.675368